Bryan Turner

Accepting PhD Students

PhD projects

The Chromatin and Gene Expression Group headed by Bryan Turner takes on doctoral researchers with an interest in epigenetics, control of differentiation, gene expression and related areas, particularly as they relate to the growth and behaviour of cancers.

In all eukaryotic organisms, from yeast to humans, DNA is packaged into the cell nucleus by complexing with a highly conserved family of proteins, the histones, to form a DNA-protein complex called chromatin. Histone modifications strongly influence the activities of genes along the DNA with which they are complexed, and play key roles in determining patterns of gene expression in both normal cells and in the deregulated cells found in diseases such as cancer. Determining the mechanisms by which histone modifications influence gene expression and whether they have a role in the heritability of gene expression patterns remain central questions in epigenetic research and ones that Professor Turner’s research group is actively pursuing.

Research activity per year

65 Article
5 Paper
3 Abstract
1 Book
More
- 1 Chapter
- 1 Review article

1 - 50 out of 76 results

2021
Histone modifications form a cell-type-specific chromosomal bar code that persists through the cell cycle
Halsall, J. A., Krueger, F., Rutledge, C. E., Ficz, G., Reik, W., Turner, B. M. & Andrews, S. R., 4 Feb 2021, In: Scientific Reports. 11, 1, 3009.
Research output: Contribution to journal › Article › peer-review

Open Access
File
249 Downloads (Pure)
2020
Morphine leads to global genome changes in H3K27me3 levels via a Polycomb Repressive Complex 2 (PRC2) self-regulatory mechanism in mESCs
Munhoa-Hoyos, I., Halsall, J., Araolaza, M., Ward, C., Garcia, I., Urizar-Arenaza, I., Gianzo, M., Garcia, P., Turner, B. & Subiran, N., 9 Nov 2020, In: Clinical epigenetics. 12, 1, p. 170
Research output: Contribution to journal › Article › peer-review

Open Access
1 Citation (Scopus)
2016
Histone deacetylase inhibitors for cancer therapy: An evolutionarily ancient resistance response may explain their limited success
Halsall, J. & Turner, B., 26 Oct 2016, In: BioEssays. 38, 11, p. 1102–1110
Research output: Contribution to journal › Article › peer-review

Open Access
File
47 Citations (Scopus)

174 Downloads (Pure)
Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes
Wiersma, M., Bussiere, M., Halsall, J. A., Turan, N., Slany, R., Turner, B. M. & Nightingale, K. P., 11 Nov 2016, In: Epigenetics & Chromatin. 9, 1, 52.
Research output: Contribution to journal › Article › peer-review

Open Access
File
6 Citations (Scopus)

189 Downloads (Pure)
2015
Cells adapt to the epigenomic disruption caused by histone deacetylase inhibitors through a coordinated, chromatin-mediated transcriptional response
Halsall, J. A., Turan, N., Wiersma, M. & Turner, B. M., 16 Sept 2015, In: Epigenetics & Chromatin. 8, 29.
Research output: Contribution to journal › Article › peer-review

Open Access
File
29 Citations (Scopus)

206 Downloads (Pure)
Immunolabelling of human metaphase chromosomes reveals the same banded distribution of histone H3 isoforms methylated at lysine 4 in primary lymphocytes and cultured cell lines
Terrenoire, E., Halsall, J. A. & Turner, B. M., 29 Apr 2015, In: BMC Genetics. 16, 1, 44.
Research output: Contribution to journal › Article › peer-review

Open Access
File
3 Citations (Scopus)

172 Downloads (Pure)
2013
Altered histone modifications in cancer
Campbell, M. J. & Turner, B. M., 2013, In: Advances in Experimental Medicine and Biology. 754, p. 81-107 27 p.
Research output: Contribution to journal › Article › peer-review
31 Citations (Scopus)
Epigenetic distortion to VDR transcriptional regulation in prostate cancer cells
Singh, P. K., Doig, C., Dhiman, V. K., Turner, B. M., Smiraglia, D. J. & Campbell, M. J., Jul 2013, In: The Journal of Steroid Biochemistry and Molecular Biology. 136, p. 258–263
Research output: Contribution to journal › Article › peer-review

Open Access
File
13 Citations (Scopus)

275 Downloads (Pure)
The histone deacetylase inhibitor sodium valproate causes limited transcriptional change in mouse embryonic stem cells but selectively overrides Polycomb-mediated Hoxb silencing
Boudadi, E., Stower, H., Halsall, J. A., Rutledge, C. E., Leeb, M., Wutz, A., O'Neill, L. P., Nightingale, K. P. & Turner, B. M., 1 May 2013, In: Epigenetics & Chromatin. 6, 1, 11.
Research output: Contribution to journal › Article › peer-review

Open Access
File
24 Citations (Scopus)

263 Downloads (Pure)
2012
Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function
Bergmann, JH., Jakubsche, JN., Martins, NM., Kagansky, A., Nakano, M., Kimura, H., Kelly, DA., Turner, B., Masumoto, H., Larionov, V. & Earnshaw, WC., 1 Jan 2012, In: Journal of Cell Science. 125, 2, p. 411-421 11 p.
Research output: Contribution to journal › Article
68 Citations (Scopus)
Genes Are Often Sheltered from the Global Histone Hyperacetylation Induced by HDAC Inhibitors.
Halsall, J., Gupta, V., O'Neill, L., Turner, B. & Nightingale, K., 1 Jan 2012, In: PLoS ONE. 7, 3, p. e33453
Research output: Contribution to journal › Article

Open Access
39 Citations (Scopus)
Itga2b regulation at the onset of definitive hematopoiesis and commitment to differentiation
Dumon, S., Walton, D. S., Wilson, N., Dassé, E., Del Pozzo, W., Landry, J-R., Turner, B., O'Neill, L. P., Göttgens, B. & Frampton, J., 2012, In: PLoS ONE. 7, 8, p. e43300
Research output: Contribution to journal › Article › peer-review

Open Access
15 Citations (Scopus)
Recruitment of NCOR1 to VDR target genes is enhanced in prostate cancer cells and associates with altered DNA methylation patterns
Doig, C. L., Singh, P. K., Dhiman, V. K., Thorne, J. L., Battaglia, S., Sobolewski, M., Maguire, O., O'Neill, L. P., Turner, B. M., McCabe, C. J., Smiraglia, D. J. & Campbell, M. J., 2012, In: Carcinogenesis.
Research output: Contribution to journal › Article › peer-review
37 Citations (Scopus)
2011
Epigenetic control of a VDR-governed feed-forward loop that regulates p21(waf1/cip1) expression and function in non-malignant prostate cells.
Thorne, JL., Maguire, O., Doig, C., Battaglia, S., Fehr, L., Sucheston, LE., Heinaniemi, M., O'Neill, L., McCabe, C., Turner, B., Carlberg, C. & Campbell, M., 1 Mar 2011, In: Nucleic Acids Research. 39, 6, p. 2045-56 12 p.
Research output: Contribution to journal › Article

Open Access
52 Citations (Scopus)
Relative overexpression of X-linked genes in mouse embryonic stem cells is consistent with Ohno's hypothesis.
Halsall, J., Antczak, P., O'Neill, L., Falciani, F. & Turner, B., 1 Jan 2011, In: Nature Genetics. 43, 12, p. 1169-70 2 p.
Research output: Contribution to journal › Article

53 Citations (Scopus)
2010
Acetylation of core histones in response to HDAC inhibitors is diminished in mitotic HeLa cells
Patzlaff, JS., Terrenoire, E., Turner, B., Earnshaw, WC. & Paulson, JR., 1 Aug 2010, In: Experimental Cell Research. 316, 13, p. 2123-2135 13 p.
Research output: Contribution to journal › Article
11 Citations (Scopus)
Environmental sensing by chromatin: An epigenetic contribution to evolutionary change.
Turner, B., 26 Nov 2010, In: FEBS Letters.
Research output: Contribution to journal › Article
19 Citations (Scopus)
Immunostaining of modified histones defines high-level features of the human metaphase epigenome.
Terrenoire, E., McRonald, F., Halsall, J., Page, P., Illingworth, RS., Taylor, A., Davison, V., O'Neill, L. & Turner, B., 1 Jan 2010, In: Genome Biology. 11, 11, p. R110
Research output: Contribution to journal › Article
34 Citations (Scopus)
Undifferentiated Embryonic Cell Transcription Factor 1 Regulates ESC Chromatin Organization and Gene Expression
Kooistra, SM., van den Boom, V., Thummer, RP., Johannes, F., Wardenaar, R., Tesson, BM., Veenhoff, LM., Fusetti, F., O'Neill, L., Turner, B., de Haan, G. & Eggen, BJL., 1 Oct 2010, In: Stem Cells. 28, 10, p. 1703-1714 12 p.
Research output: Contribution to journal › Article
24 Citations (Scopus)
2009
Elevated FOSB-expression; a potential marker of valproate sensitivity in AML.
Khanim, F., Bradbury, CA., Arrazi, J., Hayden, R., Rye, A., Basu, S., MacWhannell, A., Sawers, A., Griffiths, M., Cook, M., Freeman, S., Nightingale, K., Grimwade, D., Falciani, F., Turner, B., Bunce, C. & Craddock, C., 1 Feb 2009, In: British Journal of Haematology. 144, 3, p. 332-41 10 p.
Research output: Contribution to journal › Article
17 Citations (Scopus)
Epigenetic responses to environmental change and their evolutionary implications
Turner, B., 1 Nov 2009, In: Royal Society of London. Philosophical Transactions B. Biological Sciences. 364, 1534, p. 3403-3418 16 p.
Research output: Contribution to journal › Review article
134 Citations (Scopus)
Transcription factors, chromatin and cancer
Thorne, J., Campbell, M. & Turner, B., 1 Jan 2009, In: The International Journal of Biochemistry & Cell Biology. 41, 1, p. 164-175 12 p.
Research output: Contribution to journal › Article
30 Citations (Scopus)
Transcription-independent heritability of induced histone modifications in the mouse preimplantation embryo
VerMilyea, MD., O'Neill, L. & Turner, B., 1 Jan 2009, In: PLoS ONE. 4, 6, p. e6086
Research output: Contribution to journal › Article

Open Access
51 Citations (Scopus)
2008
Differential loss of histone H3 isoforms mono-, di- and tri-methylated at lysine 4 during X-inactivation in female embryonic stem cells
O'Neill, L., Spotswood, HT., Fernando, M. & Turner, B., 1 Apr 2008, In: Biological Chemistry. 389, 4, p. 365-70 6 p.
Research output: Contribution to journal › Article
13 Citations (Scopus)
Open chromatin and hypertranscription in embryonic stem cells
Turner, B., 8 May 2008, In: Cell stem cell. 2, 5, p. 408-10 3 p.
Research output: Contribution to journal › Article
11 Citations (Scopus)
Simplifying a complex code
Turner, B., 1 Jun 2008, In: Nature Structural and Molecular Biology. 15, 6, p. 542-544 3 p.
Research output: Contribution to journal › Article

7 Citations (Scopus)
2007
Defining an epigenetic code
Turner, B., 1 Jan 2007, In: Nature Cell Biology. 9, p. 2-6 5 p.
Research output: Contribution to journal › Article
264 Citations (Scopus)
Dosage Compensation in the Mouse Balances Up-Regulation and Silencing of X-Linked Genes
Lin, H., Gupta, V., Vermilyea, M., Falciani, F., Lee, JT., O'Neill, L. & Turner, B., 1 Jan 2007, In: PLoS Biology. 5, 12, p. e326
Research output: Contribution to journal › Article

Open Access
115 Citations (Scopus)
2006
Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells
Banwell, CM., MacCartney, DPC., Guy, M., Miles, A., Uskokovic, MR., Mansi, J., Stewart, P., O'Neill, L., Turner, B., Colston, KW. & Campbell, M., 1 Apr 2006, In: Clinical Cancer Research. 12, p. 2004-2013 10 p.
Research output: Contribution to journal › Article
66 Citations (Scopus)
Cross-talk between histone modifications in response to histone deacetylase inhibitors: MLL4 links histone H3 acetylation and histone H3K4 methylation
Nightingale, K., Gendreizig, S., White, D., Bradbury, C., Hollfelder, F. & Turner, B., 27 Nov 2006, In: Journal of Biological Chemistry. 282, p. 4408-4416 9 p.
Research output: Contribution to journal › Article
151 Citations (Scopus)
Developmental timing in Dictyostelium is regulated by the Set1 histone methyltransferase
Chubb, JR., Bloomfield, G., Xu, QK., Kaller, M., Ivens, A., Skelton, J., Turner, B., Nellen, W., Shaulsky, G., Kay, RR., Bickmore, WA. & Singer, RH., 1 Apr 2006, In: Developmental Biology. 292, 2, p. 519-532 14 p.
Research output: Contribution to journal › Article
31 Citations (Scopus)
Epigenetic characterization of the early embryo with a chromatin immunoprecipitation protocol applicable to small cell populations
O'Neill, L., Vermilyea, M. & Turner, B., 11 Jun 2006, In: Nature Genetics. 38, 7, p. 835-41 7 p.
Research output: Contribution to journal › Article
222 Citations (Scopus)
Histone modifications: signalling receptors and potential elements of a heritable epigenetic code
Nightingale, K., O'Neill, L. & Turner, B., 1 Apr 2006, In: Current Opinion in Genetics & Development. 16, p. 125-136 12 p.
Research output: Contribution to journal › Article
214 Citations (Scopus)
2005
A new map for navigating the yeast epigenome
Schubeler, D. & Turner, B., 26 Aug 2005, In: Cell. 122, p. 489-491 3 p.
Research output: Contribution to journal › Article
9 Citations (Scopus)
Epigenetic disruption in epithelial cancers of nuclear receptor-mediated dietary sensing
Campbell, M., Abedin, S., Gommersall, L., Banwell, CM., Mills, IG., Peehl, DM., Colston, KW. & Turner, B., 1 Jan 2005, In: The Alan Wolffe EMBO Conference on Chromatin and Epigenetics.
Research output: Contribution to journal › Abstract
Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors
Bradbury, C., Khanim, F., Hayden, R., Bunce, C., White, D., Drayson, M., Craddock, C. & Turner, B., 25 Aug 2005, In: Leukemia. 19, 10, p. 1751-1759 9 p.
Research output: Contribution to journal › Article
309 Citations (Scopus)
Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression which selectively changes with HDAC inhibition
Bradbury, CM., Khanim, F., Bunce, C., Drayson, M., Craddock, C. & Turner, B., 1 Jan 2005, p. 1751-1759. 9 p.
Research output: Contribution to conference (unpublished) › Paper
Reading signals on the nucleosome with a new nomenclature for modified histones
Turner, B., 1 Jan 2005, In: Nature Structural and Molecular Biology. 12, 2, p. 110-112 3 p.
Research output: Contribution to journal › Article
181 Citations (Scopus)
The Variable potency of histone deacetylase (HDAC) inhibitors to kill leukaemia cells is not defined by the HDAC expression profile of the target cells
Pearce, C., Hayden, R., Turner, B., Craddock, C., Pratt, G. & Bunce, C., 1 Jan 2005, p. 235. 1 p.
Research output: Contribution to conference (unpublished) › Paper
2004
Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells
Khanim, F., Gommersall, L., Wood, V., Smith, KL., Montalvo, L., O'Neill, L., Xu, Y., Peehl, DM., Stewart, P., Turner, B. & Campbell, M., 2 Sept 2004, In: Oncogene. 23, 40, p. 6712-25 14 p.
Research output: Contribution to journal › Article
107 Citations (Scopus)
Characterisation of Histone Deacetylase (HDAC) Expression Profiles in Acute Myeloid Leukaemia: A Basis for the Development of Targeted Therapy Using Histone Deacetylase Inhibitors
Bunce, C., Hayden, R., Khanim, F., Bradbury, C., Mehta, P., Craddock, C. & Turner, B., 1 Jan 2004, In: Blood. 104
Research output: Contribution to journal › Abstract
Chromatin and Gene Regulation: Mechanisms in Epigenetics
Turner, B., 1 Jan 2004, Blackwell Scientific Publications.
Research output: Book/Report › Book
Epigenome changes in active and inactive Polycomb group controlled regions
Breiling, A., O'Neill, L., D'Eliseo, D., Turner, B. & Orlando, V., 1 Jan 2004, In: EMBO Reports. 5, 10, p. 976-82 7 p.
Research output: Contribution to journal › Article
42 Citations (Scopus)
Nucleosome modifications and their interactions; searching for a histone code
Turner, B., 1 Jan 2004, Chromatin Structure and Dynamics.
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Sodium Valproate, when combined with all-trans retinoic acid, induces apoptosis and histone acetylation in primary blasts from patients with acute myeloid Leukaemia (AML)
Bradbury, C., Craddock, C., O'Neill, L., Drayson, M., Turner, B. & Bunce, C., 1 Jan 2004.
Research output: Contribution to conference (unpublished) › Abstract
Stress-induced transcription of satellite III repeats
Jolly, C., Metz, A., Govin, J., Vigneron, M., Turner, B., Khochbin, S. & Vourc'h, C., 5 Jan 2004, In: Journal of Cell Biology. 164, 1, p. 25-33 9 p.
Research output: Contribution to journal › Article
196 Citations (Scopus)
The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote
Schubeler, D., MacAlpine, DM., Scalzo, D., Wirbelauer, C., Kooperberg, C., van Leeuwen, F., Gottschling, D., O'Neill, L., Turner, B., Delrow, J., Bell, SP. & Groudine, M., 1 Jun 2004, In: Genes & Development. 18, p. 1263-71 9 p.
Research output: Contribution to journal › Article
613 Citations (Scopus)
2003
Histone modifications in arabidopsis – high methylation of H3 lysine 9 is dispensable for constitutive heterochromatin
Jasenkakova, Z., Soppe, W., Meister, A., Gernand, D., Turner, B. & Schubert, I., 1 Feb 2003, In: The Plant journal : for cell and molecular biology. 33, 3, p. 471-480 10 p.
Research output: Contribution to journal › Article
121 Citations (Scopus)
Immunoprecipitation of native chromatin; NChIP
O'Neill, L. & Turner, B., 1 Jan 2003, In: Methods. 31, p. 76-82 7 p.
Research output: Contribution to journal › Article
160 Citations (Scopus)
Memorable transcription
Turner, B., 1 May 2003, In: Nature Cell Biology. 5, 5, p. 390-393 4 p.
Research output: Contribution to journal › Article

29 Citations (Scopus)

Bryan Turner

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