Research output per year
Research output per year
- 1 - 50 out of 58 results
Search results
-
2023
High-force catch bonds between the Staphylococcus aureus surface protein SdrE and complement regulator factor H drive immune evasion
Paiva, T. O., Geoghegan, J. A. & Dufrêne, Y. F., 21 Mar 2023, In: Communications Biology. 6, 1, 9 p., 302.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Downloads (Pure) -
Interaction of the Staphylococcus aureus surface protein FnBPB with corneodesmosin involves two distinct, extremely strong bonds
Paiva, T. O., Viljoen, A., da Costa, T. M., Geoghegan, J. A. & Dufrêne, Y. F., 15 Feb 2023, In: ACS nanoscience Au. 3, 1, p. 58-66 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Downloads (Pure) -
Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles
Muñoz-Wolf, N., Ward, R. W., Hearnden, C. H., Sharp, F. A., Geoghegan, J., O'Grady, K., McEntee, C. P., Shanahan, K. A., Guy, C., Bowie, A. G., Campbell, M., Roces, C. B., Anderluzzi, G., Webb, C., Perrie, Y., Creagh, E. & Lavelle, E. C., 17 Jan 2023, In: Cell Reports Medicine. 4, 1, 21 p., 100899.Research output: Contribution to journal › Article › peer-review
Open AccessFile42 Downloads (Pure) -
Recruitment of C4b-binding protein is not a complement evasion strategy employed by Staphylococcus aureus
Li, S., Bettoni, S., Mohlin, F., Geoghegan, J. A., Blom, A. M. & Laabei, M., 5 Sept 2023, In: Microbiology. 169, 9, 10 p., 001391.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Downloads (Pure) -
Staphylococcal Periscope Proteins Aap, SasG and Pls project non-canonical legume-like lectin adhesin domains from the bacterial surface
Clark, L. C., Atkin, K. E., Whelan, F., Brentnall, A. S., Harris, G., Towell, A. M., Turkenburg, J. P., Liu, Y., Feizi, T., Griffiths, S. C., Geoghegan, J. A. & Potts, J. R., 4 Mar 2023, In: The Journal of biological chemistry. 299, 3, 11 p., 102936.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Downloads (Pure) -
The A domain of clonal complex 1-type fibronectin binding protein B promotes adherence and biofilm formation in Staphylococcus aureus
Henderson, S. R. & Geoghegan, J. A., 16 Jun 2023, In: Microbiology. 169, 6, 10 p., 001348.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Downloads (Pure) -
The mutational landscape of Staphylococcus aureus during colonisation
Geoghegan, J., 2023, (Submitted).Research output: Working paper/Preprint › Preprint
-
von Willebrand factor-binding protein (vWbp)-activated factor XIII and transglutaminase 2 (TG2) promote cross-linking between FnBPA from Staphylococcus aureus and fibrinogen
Motta, C., Pellegrini, A., Camaione, S., Geoghegan, J., Speziale, P., Barbieri, G. & Pietrocola, G., 19 Jul 2023, In: Scientific Reports. 13, 1, 13 p., 11683 .Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Downloads (Pure) -
2022
Allantodapsone is a Pan-Inhibitor of Staphylococcus aureus Adhesion to Fibrinogen, Loricrin, and Cytokeratin 10
Prencipe, F., Alsibaee, A., Khaddem, Z., Norton, P., Towell, A. M., Ali, A. F. M., Reid, G., Fleury, O. M., Foster, T. J., Geoghegan, J. A., Rozas, I. & Brennan, M. P., 1 Jun 2022, (E-pub ahead of print) In: Microbiology spectrum. 10, 3, 13 p., e0117521.Research output: Contribution to journal › Article › peer-review
Open AccessFile40 Downloads (Pure) -
Fibronectin binding protein B binds to loricrin and promotes corneocyte adhesion by Staphylococcus aureus
da Costa, T. M., Viljoen, A., Towell, A. M., Dufrêne, Y. F. & Geoghegan, J. A., Dec 2022, In: Nature Communications. 13, 1, 11 p., 2517.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Downloads (Pure) -
2021
Enantioselective effect of cysteine functionalized mesoporous silica nanoparticles in U87 MG and GM08680 human cells and Staphylococcus aureus bacteria
Martínez-Carmona, M., Cela, C., Kuznetsova, V. A., Geoghegan, J. A. & Gun'ko, Y. K., 28 Apr 2021, In: Journal of Materials Chemistry B. 9, 16, p. 3544-3553 10 p.Research output: Contribution to journal › Article › peer-review
-
Staphylococcus aureus binds to the N-terminal region of corneodesmosin to adhere to the stratum corneum in atopic dermatitis
Towell, A. M., Feuillie, C., Vitry, P., Da Costa, T. M., Mathelié-Guinlet, M., Kezic, S., Fleury, O. M., McAleer, M. A., Dufrêne, Y. F., Irvine, A. D. & Geoghegan, J. A., 5 Jan 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 1, 9 p., e2014444118.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)120 Downloads (Pure) -
2020
Dysregulated skin barrier function in Tmem79 mutant mice promotes IL-17A-dependent spontaneous skin and lung inflammation
Saunders, S. P., Floudas, A., Moran, T., Byrne, C. M., Rooney, M. D., Fahy, C. M. R., Geoghegan, J. A., Iwakura, Y., Fallon, P. G. & Schwartz, C., 9 Jul 2020, (E-pub ahead of print) In: Allergy. 75, 12, p. 3216-3227Research output: Contribution to journal › Article › peer-review
-
Editorial overview: Bacterial regulatory hierarchies and networks
Dorman, C. J. & Geoghegan, J., Jun 2020, In: Current Opinion in Microbiology. 55, p. iii-vResearch output: Contribution to journal › Article
-
Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin
Olatunji, S., Yu, X., Bailey, J., Huang, C-Y., Zapotoczna, M., Bowen, K., Remškar, M., Müller, R., Scanlan, E. M., Geoghegan, J. A., Olieric, V. & Caffrey, M., Dec 2020, In: Nature Communications. 11, 1, 11 p., 140.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)150 Downloads (Pure) -
2019
Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target
Lacey, K. A., Mulcahy, M. E., Towell, A. M., Geoghegan, J. A. & McLoughlin, R. M., Apr 2019, In: PLoS pathogens. 15, 4, p. e1007713Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
Fibronectin-binding protein B (FnBPB) from Staphylococcus aureus protects against the antimicrobial activity of histones
Pietrocola, G., Nobile, G., Alfeo, M. J., Foster, T. J., Geoghegan, J. A., De Filippis, V. & Speziale, P., 8 Mar 2019, In: The Journal of biological chemistry. 294, 10, p. 3588-3602 15 p.Research output: Contribution to journal › Article › peer-review
-
Host-specialized fibrinogen-binding by a bacterial surface protein promotes biofilm formation and innate immune evasion
Pickering, A. C., Vitry, P., Prystopiuk, V., Garcia, B., Höök, M., Schoenebeck, J., Geoghegan, J. A., Dufrêne, Y. F. & Fitzgerald, J. R., Jun 2019, In: PLoS pathogens. 15, 6, p. e1007816Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus) -
2018
Adhesion of Staphylococcus aureus to Corneocytes from Atopic Dermatitis Patients Is Controlled by Natural Moisturizing Factor Levels
Feuillie, C., Vitry, P., McAleer, M. A., Kezic, S., Irvine, A. D., Geoghegan, J. A. & Dufrêne, Y. F., 14 Aug 2018, In: mBio. 9, 4Research output: Contribution to journal › Article › peer-review
30 Citations (Scopus) -
A horizontally gene transferred copper resistance locus confers hyper-resistance to antibacterial copper toxicity and enables survival of community acquired methicillin resistant Staphylococcus aureus USA300 in macrophages.
Purves, J., Thomas, J., Riboldi, GP., Zapotoczna, M., Tarrant, E., Andrew, PW., Londoño, A., Planet, PJ., Geoghegan, JA., Waldron, KJ. & Morrissey, JA., Mar 2018, In: Environmental Microbiology. 20, 4, p. 1576-1589Research output: Contribution to journal › Article › peer-review
-
Mechanomicrobiology: How Mechanical Forces Activate Staphylococcus aureus Adhesion.
Geoghegan, JA. & Dufrêne, YF., Jun 2018, In: Trends in Microbiology. 26, 8, p. 645-648Research output: Contribution to journal › Article › peer-review
-
Mobile-genetic-element-encoded hypertolerance to copper protects Staphylococcus aureus from killing by host phagocytes
Zapotoczna, M., Riboldi, G. P., Moustafa, A. M., Dickson, E., Narechania, A., Morrissey, J. A., Planet, P. J., Holden, M. T. G., Waldron, K. J. & Geoghegan, J. A., 16 Oct 2018, In: mBio. 9, 5, 15 p., e00550-18.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)116 Downloads (Pure) -
Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship
Geoghegan, J. A., Irvine, A. D. & Foster, T. J., Jun 2018, In: Trends in Microbiology. 26, 6, p. 484-497 14 p.Research output: Contribution to journal › Review article › peer-review
123 Citations (Scopus) -
Staphylococcus aureus clumping factor A is a force-sensitive molecular switch that activates bacterial adhesion
Herman-Bausier, P., Labate, C., Towell, A. M., Derclaye, S., Geoghegan, J. A. & Dufrêne, Y. F., 22 May 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 21, p. 5564-5569 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile44 Citations (Scopus)100 Downloads (Pure) -
The widespread use of topical antimicrobials enriches for resistance in Staphylococcus aureus isolated from patients with atopic dermatitis
Harkins, C. P., McAleer, M. A., Bennett, D., McHugh, M., Fleury, O. M., Pettigrew, K. A., Oravcová, K., Parkhill, J., Proby, C. M., Dawe, R. S., Geoghegan, J. A., Irvine, A. D. & Holden, M. T. G., Oct 2018, In: British Journal of Dermatology. 179, 4, p. 951-958 8 p.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus) -
2017
Clumping factor B promotes adherence of Staphylococcus aureus to corneocytes in atopic dermatitis
Fleury, O. M., McAleer, M. A., Feuillie, C., Formosa-Dague, C., Sansevere, E., Bennett, D. E., Towell, A. M., McLean, W. H. I., Kezic, S., Robinson, D. A., Fallon, P. G., Foster, T. J., Dufrêne, Y. F., Irvine, A. D. & Geoghegan, J. A., 23 May 2017, In: Infection and Immunity. 85, 6, 12 p., e00994-16.Research output: Contribution to journal › Article › peer-review
Open Access42 Citations (Scopus) -
Conjugate of an IgG Binding Domain with Botulinum Neurotoxin A Lacking the Acceptor Moiety Targets Its SNARE Protease into TrkA-Expressing Cells When Coupled to Anti-TrkA IgG or Fc-βNGF.
Nugent, M., Wang, J., Lawrence, G., Zurawski, T., Geoghegan, JA. & Dolly, JO., May 2017, In: Bioconjugate Chemistry. 28, 6, p. 1684-1692Research output: Contribution to journal › Article › peer-review
-
Force-Induced Strengthening of the Interaction between Staphylococcus aureus Clumping Factor B and Loricrin
Vitry, P., Valotteau, C., Feuillie, C., Bernard, S., Alsteens, D., Geoghegan, J. A. & Dufrêne, Y. F., 5 Dec 2017, In: mBio. 8, 6Research output: Contribution to journal › Article › peer-review
-
Live-Cell Nanoscopy in Antiadhesion Therapy.
Geoghegan, JA., Foster, TJ., Speziale, P. & Dufrêne, YF., 1 May 2017, In: Trends in Microbiology.Research output: Contribution to journal › Article › peer-review
-
Molecular interactions and inhibition of the staphylococcal biofilm-forming protein SdrC
Feuillie, C., Formosa-Dague, C., Hays, L. M. C., Vervaeck, O., Derclaye, S., Brennan, M. P., Foster, T. J., Geoghegan, J. & Dufrêne, Y. F., 4 Apr 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 14, p. 3738-3743 6 p.Research output: Contribution to journal › Article › peer-review
49 Citations (Scopus) -
The Staphylococcus aureus Cell Wall-Anchored Protein Clumping Factor A Is an Important T Cell Antigen
Lacey, K. A., Leech, J. M., Lalor, S. J., McCormack, N., Geoghegan, J. A., McLoughlin, R. M. & Freitag, N. E. (ed.), Dec 2017, In: Infection and Immunity.Research output: Contribution to journal › Article › peer-review
-
2016
CRIg Functions as a Macrophage Pattern Recognition Receptor to Directly Bind and Capture Blood-Borne Gram-Positive Bacteria.
Zeng, Z., Surewaard, BG., Wong, CH., Geoghegan, JA., Jenne, CN. & Kubes, P., Jun 2016, In: Cell Host & Microbe. 20, 1, p. 99-106Research output: Contribution to journal › Article › peer-review
-
Lessons from the Crystal Structure of the S. aureus Surface Protein Clumping Factor A in Complex With Tefibazumab, an Inhibiting Monoclonal Antibody.
Ganesh, VK., Liang, X., Geoghegan, JA., Cohen, ALV., Venugopalan, N., Foster, TJ. & Hook, M., Oct 2016, In: EBioMedicine. 13, p. 328-338Research output: Contribution to journal › Article › peer-review
-
The Role of Staphylococcus aureus Virulence Factors in Skin Infection and Their Potential as Vaccine Antigens.
Lacey, KA., Geoghegan, JA. & McLoughlin, RM., Feb 2016, In: Pathogens (Basel, Switzerland).Research output: Contribution to journal › Article › peer-review
-
Zinc-dependent mechanical properties of Staphylococcus aureus biofilm-forming surface protein SasG
Formosa-Dague, C., Speziale, P., Foster, T. J., Geoghegan, J. A. & Dufrêne, Y. F., 12 Jan 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 2, p. 410-415 6 p.Research output: Contribution to journal › Article › peer-review
89 Citations (Scopus) -
2015
Biofilm formation by staphylococci and streptococci: structural, functional, and regulatory aspects and implications for pathogenesis.
Speziale, P. & Geoghegan, JA., 2015, In: Frontiers in cellular and infection microbiology.Research output: Contribution to journal › Article › peer-review
-
Cell Wall-Anchored Surface Proteins of Staphylococcus aureus: Many Proteins, Multiple Functions
Geoghegan, J. & Foster, T. J., 15 Dec 2015, In: Current Topics in Microbiology and Immunology. 409, p. 95-120 26 p.Research output: Contribution to journal › Article › peer-review
23 Citations (Scopus) -
Fibronectin Binding Proteins SpsD and SpsL Both Support Invasion of Canine Epithelial Cells by Staphylococcus pseudintermedius.
Pietrocola, G., Gianotti, V., Richards, A., Nobile, G., Geoghegan, JA., Rindi, S., Monk, IR., Bordt, AS., Fitzgerald, JR. & Speziale, P., 2 Oct 2015, In: Infection and Immunity. 83, 10, p. 4093-4102Research output: Contribution to journal › Article › peer-review
-
Manipulation of Autophagy in Phagocytes Facilitates Staphylococcus aureus Bloodstream Infection.
O'Keeffe, KM., Wilk, MM., Leech, JM., Murphy, AG., Laabei, M., Monk, IR., Massey, RC., Lindsay, JA., Foster, TJ., Geoghegan, JA. & McLoughlin, RM., Sept 2015, In: Infection and Immunity. 83, 9Research output: Contribution to journal › Article › peer-review
-
Memory Th1 cells are protective in invasive staphylococcus aureus infection
Brown, A. F., Murphy, A. G., Lalor, S. J., Leech, J. M., O'Keeffe, K. M., Mac Aogáin, M., O'Halloran, D. P., Lacey, K. A., Tavakol, M., Hearnden, C. H., Fitzgerald-Hughes, D., Humphreys, H., Fennell, J. P., van Wamel, W. J., Foster, T. J., Geoghegan, J. A., Lavelle, E. C., Rogers, T. R. & McLoughlin, R. M., 5 Nov 2015, In: PLoS pathogens. 11, 11, 32 p., e1005226.Research output: Contribution to journal › Article › peer-review
Open AccessFile91 Citations (Scopus)152 Downloads (Pure) -
Protein A is released into the Staphylococcus aureus culture supernatant with an unprocessed sorting signal.
O'Halloran, DP., Wynne, K. & Geoghegan, JA., Apr 2015, In: Infection and Immunity. 83, 4Research output: Contribution to journal › Article › peer-review
-
Staphylococcus aureus Fibronectin-Binding Protein A Mediates Cell-Cell Adhesion through Low-Affinity Homophilic Bonds.
Herman-Bausier, P., El-Kirat-Chatel, S., Foster, TJ., Geoghegan, JA. & Dufrêne, YF., 2015, In: mBio. 6, 3Research output: Contribution to journal › Article › peer-review
-
Staphylokinase controls Staphylococcus aureus biofilm formation and detachment through host plasminogen activation.
Kwiecinski, J., Peetermans, M., Liesenborghs, L., Na, M., Björnsdottir, H., Zhu, X., Jacobsson, G., Johansson, BR., Geoghegan, JA., Foster, TJ., Josefsson, E., Bylund, J., Verhamme, P. & Jin, T., Jul 2015, In: The Journal of Infectious Diseases. 213, 1, p. 139-148Research output: Contribution to journal › Article › peer-review
-
2014
Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus.
Geoghegan, JA., Ganesh, VK. & Höök, M., Jan 2014, In: Nature Reviews Microbiology.Research output: Contribution to journal › Article › peer-review
-
A short sequence within subdomain N1 of region A of the Staphylococcus aureus MSCRAMM clumping factor A is required for export and surface display.
McCormack, N., Foster, TJ. & Geoghegan, JA., 20 Apr 2014, In: Microbiology.Research output: Contribution to journal › Article › peer-review
-
Fibronectin-binding proteins are required for biofilm formation by community-associated methicillin-resistant Staphylococcus aureus strain LAC.
McCourt, J., O'Halloran, DP., McCarthy, H., O'Gara, JP. & Geoghegan, JA., Apr 2014, In: FEMS Microbiology Letters.Research output: Contribution to journal › Article › peer-review
-
IsdC from Staphylococcus lugdunensis induces biofilm formation under low-iron growth conditions.
Missineo, A., Di, P. A., Geoghegan, JA., Rindi, S., Heilbronner, S., Gianotti, V., Arciola, CR., Foster, TJ., Speziale, P. & Pietrocola, G., Jun 2014, In: Infection and Immunity. 82, 6Research output: Contribution to journal › Article › peer-review
-
Protein-based biofilm matrices in Staphylococci.
Speziale, P., Pietrocola, G. & Geoghegan, JA., 2014, In: Frontiers in cellular and infection microbiology.Research output: Contribution to journal › Article › peer-review
-
Role for the A domain of unprocessed accumulation-associated protein (Aap) in the attachment phase of the Staphylococcus epidermidis biofilm phenotype.
Conlon, BP., Geoghegan, JA., Waters, EM., McCarthy, H., Rowe, SE., Davies, JR., Schaeffer, CR., Foster, TJ., Fey, PD. & O'Gara, JP., Dec 2014, In: Journal of Bacteriology. 196, 24Research output: Contribution to journal › Article › peer-review
-
Targeted nasal vaccination provides antibody-independent protection against Staphylococcus aureus.
Misstear, K., McNeela, EA., Murphy, AG., Geoghegan, JA., O'Keeffe, KM., Fox, J., Chan, K., Heuking, S., Collin, N., Foster, TJ., McLoughlin, RM. & Lavelle, EC., May 2014, In: The Journal of Infectious Diseases. 209, 9, p. 1479-1484Research output: Contribution to journal › Article › peer-review